The Mouse Phenotype Database consists of the raw data of behavioral tests from the mice strain that are published in the following articles:

1. Arron JR, Winslow MM, Polleri A, Chang CP, Wu H, Gao X, Neilson JR, Chen L, Heit JJ, Kim SK, Yamasaki N, Miyakawa T, Francke U, Graef IA, Crabtree GR. NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature 2006, 441(7093), 595-600

2. Ihara M, Yamasaki N, Hagiwara A, Tomimoto H, Kitano A, Tanigaki A, Hikawa E, Noda M, Takanashi M, Hattori N, Miyakawa T, Kinoshita M. Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity. Neuron 2007, 53(4), 519-533

3. Hattori S, Hashimoto R, Miyakawa T, Yamanaka H, Maeno H, Wada K, Kunugi H. Enriched environments influence depression-related behavior in adult mice and the survival of newborn cells in their hippocampi. Behaviroural Brain Research 2007, 180(1), 69-76

4. Niemann S, Kanki H, Fukui Y, Takao K, Fukaya M, Hynynen MN, Churchill MJ, Shefner JM, Bronson RT, Watanabe M, Brown RH, Jr., Miyakawa T, Itohara S, Hayashi Y. Genetic ablation of NMDA receptor subunit NR3B in mouse reveals motoneuronal and non-motoneuronal phenotypes. European Journal of Neuroscience 2007, 26(6), 1407-1420

5. Shibata M, Yamasaki N, Miyakawa T, Ohtani R, Ihara M, Takahashi R, Tomimoto H. Selective impairment of working memory in a mouse model of chronic cerebral hypoperfusion. Stroke 2007, 38(10), 2826-2832

6. Ogawa M, Miyakawa T, Nakamura K, Kitano J, Furushima K, Kiyonari H, Nakao K, Moriyoshi K, Nakanishi S. Altered sensitivities to morphine and cocaine in scaffold protein tamalin knock out mice. Proc. Natl. Acad. Sci. USA 2007, 104(37), 14789-14794

7. Sano H, Nagai Y, Miyakawa T, Shigemoto R, Yokoi M. Increased social interaction in mice deficient of the striatal medium spiny neuron-specific phosphodiesterase 10A2. Journal of Neurochemistry 2008, 105(2), 546-556

8. Horii Y, Yamasaki N, Miyakawa T, Shiosaka S. Increased anxiety-like behavior in neuropsin (kallikrein-related peptidase 8) gene-deficient mice. Behavioral Neuroscience 2008, 122(3), 498-504

9. Fukuda E, Hamada S, Hasegawa S, Katori S, Sanbo M, Miyakawa T, Yamamoto T, Yamamoto H, Hirabayashi T, Yagi T. Down-regulation of protocadherin-alpha, A isoforms in mice changes contextual fear conditioning and spatial working memory. European Journal of Neuroscience2008, 28(7): 1362-1376

10. Sakae N, Yamasaki N, Kitaichi K, Fukuda T, Yamada M, Yoshikawa H, Hiranita T, Tatsumi Y, Kira J, Yamamoto T, Miyakawa T, Nakayama KI. Mice lacking the schizophrenia-associated protein FEZ1 manifest hyperactivity and enhanced responsiveness to psychostimulants. Human Molecular Genetics 2008, 17(20): 3191-3203

11. Ikeda M, Hikita T, Taya S, Uraguchi-Asaki J, Toyo-oka K, Wynshaw-Boris A, Ujike H, Inada T, Takao K, Miyakawa T, Ozaki N, Kaibuchi K, Iwata N. Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia. Human Molecular Genetics 2008, 17(20): 3212-3222

12. Imayoshi I, Sakamoto M, Ohtsuka T, Takao K, Miyakawa T, Yamaguchi M, Mori K, Ikeda T, Itohara S, Kageyama R. Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nature Neuroscience 2008, 11, 1153-1161

13. Tsujimura A, Matsuki M, Takao K, Yamanishi K, Miyakawa T and Hashimoto-Gotoh T, Mice lacking the kf-1 gene exhibit increased anxiety- but not despair-like behavior. Front. Behav. Neurosci. 2008, 2:4

14. Yamasaki N, Maekawa M, Kobayashi K, Kajii Y, Maeda J, Soma M, Takao K, Tanda K, Ohira K, Toyama T, Kanzaki K, Fukunaga K, Sudo Y, Ichinose H, Ikeda M, Iwata N, Ozaki N, Suzuki H, Higuchi M, Suhara T, Yuasa S, Miyakawa T., Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders, Molecular Brain 2008, 1: 6

15. Nakajima R, Takao K, Huang SM, Takano J, Iwata N, Miyakawa T, Saido TC, Comprehensive behavioral phenotyping of calpastatin-knockout mice, Molecular Brain 2008, 1: 7

16. Takao K, Toyama K, Nakanishi K, Hattori S, Takamura H, Takeda M, Miyakawa T, Hashimoto R, Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia, Molecular Brain 2008, 1:11

17. Tanaka H, Ma J, Tanaka K, Takao K, Komada M, Tanda, K, Suzukki A, Ishibashi T, Baba H, Isa T, Shigemoto R, Ono K, Miyakawa T, Ikenaka, K, Mice with altered myelin proteolipid protein gene expression display cognitive deficits accompanied by abnormal neuron-glia interactions and decreased conduction velocities, Journal of Neuroscience 2009, 29(26):8363-8371

18. Matsuo N, Tanda K, Nakanishi K, Yamasaki N, Toyama K, Takao K, Takeshima H, Miyakawa T, Comprehensive behavioral phenotyping of ryanodine receptor type3 (RyR3) knockout mice: Decreased social contact duration in two social interaction tests, Frontiers in Behavioral Neuroscience 2009, 3:3

19. Tanda K, Nishi A, Matsuo N, Nakanishi K, Yamasaki N, Sugimoto T, Toyama K, Takao K, Miyakawa T, Abnormal social behavior, hyperactivity, impaired remote spatial memory, and increased D1-mediated dopaminergic signaling in neuronal nitric oxide synthase knockout mice, Molecular Brain 2009, 2:19

20. Nakatani J, Tamada K, Hatanaka F, Ise S, Ohta H, Inoue K, Tomonaga S, Watanabe Y, Chung YJ, Banerjee R, Iwamoto K, Kato T, Okazawa M, Yamauchi K, Tanda K, Takao K, Miyakawa T, Bradley A, Takumi T, Abnormal Behavior in a Chromosome- Engineered Mouse Model for Human 15q11-13 Duplication Seen in Autism, Cell 2009, 137(7): 1235-1246

21. Yamada M, Yoshida Y, Mori D, Takitoh T, Kengaku M, Umeshima H, Takao K, Miyakawa T, Sato M, Sorimachi H, Wynshaw-Boris A, Hirotsune S, Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly, Nature Medicine 2009, 15(10), 1202-7

22.Ohno M, Hiraoka Y, Matsuoka T, TOmimoto H, Takao K, Miyakawa T, Oshima N, Kiyonari H, Kimura T, Kita T, Nishi E, Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system, Nature Neuroscience 2009, 12, 1506 - 1513

23.Kaidanovich-Beilin O, Lipina TV, Takao K, van Eede M, Hattori S, Laliberté C, Khan M, Okamoto K, Chambers JW, Fletcher PJ, MacAulay K, Doble BW, Henkelman M, Miyakawa T, Roder J, Woodgett JR., Abnormalities in brain structure and behavior in GSK-3alpha mutant mice, Molecular Brain 2009, 2:35

24.Takao K, Tanda K, Nakamura K, Kasahara J, Nakao K, Katsuki M, Nakanishi K, Yamasaki N, Toyama K, Adachi M, Umeda M, Araki T, Fukunaga K, Kondo H, Sakagami H, Miyakawa T, Comprehensive behavioral analysis of calcium/calmodulin-dependent protein kinase IV knockout mice, PLoS ONE 2010, 5(3): e9460

25. Matsuo N, Takao K, Nakanishi K, Yamasaki N, Tanda K, Miyakawa T, Behavioral profiles of three C57BL/6 substrains, Frontiers in Behavioral Neuroscience 2010, 4:29

26. Nishio K, Ihara M, Yamasaki N, Kalaria RN, Maki T, Fujita Y, Ito H, Oishi N, Fukuyama H, Miyakawa T, Takahashi R, Tomimoto H, A mouse model characterizing features of vascular dementia with hippocampal atrophy. Stroke 2010,41: 1278-1284

27. Ohnishi H, Murata T, Kusakari S, Hayashi Y, Takao K, Maruyama T, Ago Y, Koda K, Jin FJ, Okawa K, Oldenborg PA, Okazawa H, Murata Y, Furuya N, Matsuda T, Miyakawa T, Matozaki T,Stress-Evoked Tyrosine Phosphorylation of Signal Regulatory Protein α Regulates Behavioral Immobility in the Forced Swim Tes, Journal of Neuroscience 2010, 30(31): 10472-10483

28. Sagata N, Iwaki A, Aramaki T, Takao K, Kura S, Tsuzuki T, Kawakami R, Ito I, Kitamura T, Sugiyama H, Miyakawa T, Fukumaki Y, Comprehensive behavioral study of GluR4 knockout mice, implication in cognitive function, Genes, Brain and Behavior, 2010 Nov;9(8):899-909

29. Tamada K, Tomonaga S, Hatanaka F, Nakai N, Takao K, Miyakawa T, Nakatani J, Takumi T, Decreased exploratory activity in a mouse model of 15q duplication syndrome; implications for disturbance of serotonin signaling, PLoS One, 2010, 5(12):e15126

30. Yamanaka Y, Kitano A, Takao K, Prasansuklab A, Mushiroda T, Yamazaki K, Kumada T, Shibata M, Takaoka Y, Awaya T, Kato T, Abe T, Iwata N, Miyakawa T, Nakamura Y, Nakahata T, Heike T, Inactivation of fiboblast grwoth factor binding protein 3 causes anxiety-related behaviors, Molecular Cellular Neuroscience 2011 Jan;46(1):200-12

31. Yamada M, Ihara M, Okamoto Y, Maki T, Washida K, Kitamura A, Hase Y, Ito H, Takao K, Miyakawa T, Kalaria RN, Tomimoto H, Takahashi R, The influence of chronic cerebral hypoperfusion on cognitive function and amyloid beta metabolism in APP overexpressing mice, PLoS One 2011 Jan 27;6(1):e16567

32. Yao I, Takao K, Miyakawa T, Ito S, Setou M, Synaptic E3 ligase SCRAPPER in contextual fear conditioning: extensive behavioral phenotyping of Scrapper heterozygote and overexpressing mutant mice, PLoS One 2011 Feb 24;6(2):e17317

33. Kaitsuka T, Li ST, Nakamura K, Takao K, Miyakawa T, Matsushita M, Forebrain-specific constitutively active CaMKKalpha transgenic mice show deficits in hippocampus-dependent long-term memory, Neurobiology of Learning and Memory 2011, 96(2):238-47

34. Takeuchi H, Iba M, Inoue H, Higuchi M, Takao K, Tsukita K, Karatsu Y, Iwamoto Y, Miyakawa T, Suhara T, Trojanowski JQ, Lee VM, Takahashi R, P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating, PLoS One 2011, 6(6):e21050

35. Watanabe Y, Tsujimura A, Takao K, Nishi K, Ito Y, Yasuhara Y, Nakatomi Y, Yokoyama C, Fukui K, Miyakawa T, Tanaka M, Relaxin-3-deficient mice showed slight alteration in anxiety-related behavior. Frontiers in Behavioral Neuroscience, 2011;5:50

36. Asrar S, Kaneko K, Takao K, Negandhi J, Matsui M, Shibasaki K, Miyakawa T, Harrison RV, Jia Z, Salter MW, Tominaga M, Fukumi-Tominaga T, DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze, Mol Brain, 2011;4:39

37. Suzuki K, Zhou J, Sato T, Takao K, Miyagawa T, Oyake M, Yamada M, Takahashi H, Takahashi Y, Goto J, Tsuji S, DRPLA transgenic mouse substrains carrying single copy of full-length mutant human DRPLA gene with variable sizes of expanded CAG repeats exhibit CAG repeat length- and age-dependent changes in behavioral abnormalities and gene expression profiles. Neurobiol Dis. 2012 46(2):336-50.

38. Koshimizu H, Fukui Y, Takao K, Ohira K, Tanda K, Nakanishi K, Toyama K, Oshima M, Taketo MM, Miyakawa T, Adenomatous polyposis coil heterozygous knockout mice display hypoactivity and age-dependent working memory deficits. Front Behav Neurosci, 2011;5:85

39. Yamakado H, Moriwaki Y, Yamasaki N, Miyakawa T, Kurisu J, Uemura K, Inoue H, Takahashi M, Takahashi R, α-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotion. Neurosci Res, 2012 73(2):173-7

40. Hattori S, Takao K, Tanda K, Toyama K, Shintani N, Baba A, Hashimoto H, Miyakawa T. Comprehensive behavioral analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) knockout mice. Front Behav Neurosci. 2012;6:58.

41. Nagura H, Ishikawa Y, Kobayashi K, Takao K, Tanaka T, Nishikawa K, Tamura H, Shiosaka S, Suzuki H, Miyakawa T, Fujiyoshi Y, Doi T. Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 knockin mice. Mol Brain. 2012;5:43.

42. Komine Y, Takao K, Miyakawa T, Yamamori T. Behavioral abnormalities observed in zfhx2-deficient mice. PLoS One. 2012;7(12):e53114.

43. Takao K, Kobayashi K, Hagihara H, Ohira K, Shoji H, Hattori S, Koshimizu H, Umemori J, Toyama K, Nakamura HK, Kuroiwa M, Maeda J, Atsuzawa K, Esaki K, Yamaguchi S, Furuya S, Takagi T, Walton NM, Hayashi N, Suzuki H, Higuchi M, Usuda N, Suhara T, Nishi A, Matsumoto M, Ishii S, Miyakawa T. Deficiency of Schnurri-2, an MHC Enhancer Binding Protein, Induces Mild Chronic Inflammation in the Brain and Confers Molecular, Neuronal, and Behavioral Phenotypes Related to Schizophrenia. Neuropsychopharmacology. 2013; doi: 10.1038/npp.2013.38.

44. Ohira K, Kobayashi K, Toyama K, Nakamura HK, Shoji H, Takao K, Takeuchi R, Yamaguchi S, Kataoka M, Otsuka S, Takahashi M, Miyakawa T. Synaptosomal-associated protein 25 mutation induces immaturity of the dentate granule cells of adult mice. Molecular Brain 2013 6:12.

45. Umemori J, Takao K, Koshimizu H, Hattori S, Furuse T, Wakana S, Miyakawa T.ENU-mutagenesis mice with a non-synonymous mutation in Grin1 exhibit abnormal anxiety-like behaviors, impaired fear memory, and decreased acoustic startle response. BMC Res Notes. 2013;6:203. doi: 10.1186/1756-0500-6-203.

46. Ageta-Ishihara N, Yamakado H, Morita T, Hattori S, Takao K, Miyakawa T, Takahashi R, Kinoshita M.Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson's disease, causes behavioral alterations but not neurodegeneration in mice. Mol Brain. 2013;6:35

47. Watanabe Y, Katayama N, Takeuchi K, Togano T, Itoh R, Sato M, Yamazaki M, Abe M, Sato T, Oda K, Yokoyama M, Takao K, Fukaya M, Miyakawa T, Watanabe M, Sakimura K, Manabe T, Igarashi M. Point Mutation in Syntaxin-1A Causes Abnormal Vesicle Recycling, Behaviors, and Short Term Plasticity. J Biol Chem. 2013;288(48):34906-19.

48. Yamashita N, Takahashi A, Takao K, Yamamoto T, Kolattukudy P, Miyakawa T, Goshima Y. Mice lacking collapsin response mediator protein 1 manifest hyperactivity, impaired learning and memory, and impaired prepulse inhibition. Front Behav Neurosci. 2013; doi: 10.3389/fnbeh.2013.00216.

49. Kobayashi M, Nakatani T, Koda T, Matsumoto K, Ozaki R, Mochida N, Takao K, Miyakawa T, Matsuoka I. Absence of BRINP1 in mice causes increase of hippocampal neurogenesis and behavioral alterations relevant to human psychiatric disorders. Molecular Brain, 2014, 7:12

50. Koshimizu H, Takao K, Matozaki T, Ohnishi H, Miyakawa T. Comprehensive behavioral analysis of cluster of differentiation 47 knockout mice. PLoS One, 2014, 9(2):e89584

51. Fujioka R, Nii T, Iwaki A, Shibata A, Ito I, Kitaichi K, Nomura M, Hattori S, Takao K, Miyakawa T, Fukumaki Y. Comprehensive behavioral study of mGluR3 knockout mice: implication in schizophrenia related endophenotypes. Molecular Brain, 2014, 7:31

52. Zheng LS, Hitoshi S, Kaneko N, Takao K, Miyakawa T, Tanaka Y, Xia H, Kalinke U, Kudo K, Kanba S, Ikenaka K, Sawamoto K. Mechanisms for Interferon-α-Induced Depression and Neural Stem Cell Dysfunction. Stem Cell Reports, 2014, 3(1):73-84

53. Watanabe S, Ageta-Ishihara N, Nagatsu S, Takao K, Komine O, Endo F, Miyakawa T, Misawa H, Takahashi R, Kinoshita M, Yamanaka K. SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system. Molecular Brain, 2014, 7:62

54. Yasumura M, Yoshida T, Yamazaki M, Abe M, Natsume R, Kanno K, Uemura T, Takao K, Sakimura K, Kikusui T, Miyakawa T, Mishina M. IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours. Sci Rep. 2014, 4:6613

55. Shibasaki K, Sugio S, Takao K, Yamanaka A, Miyakawa T, Tominaga M, Ishizaki Y. TRPV4 activation at the physiological temperature is a critical determinant of neuronal excitability and behavior. Pflugers Arch. 2015, online

57. Shoji H, Takao K, Hattori S, Miyakawa T. Age-related changes in behavior in C57BL/6J mice from young adulthood to middle age. Mol Brain. 2016 Jan 28;9(1):11.

58. Ohashi R, Takao K, Miyakawa T, Shiina N. Comprehensive behavioral analysis of RNG105 (Caprin1) heterozygous mice: Reduced social interaction and attenuated response to novelty. Sci Rep. 2016 Feb 11;6:20775

59. Ip JY, Sone M, Nashiki C, Pan Q, Kitaichi K, Yanaka K, Abe T, Takao K, Miyakawa T, Blencowe BJ, Nakagawa S. Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine. Sci Rep. 2016 Jun 2;6:27204